Methylamine → N-{2-(Methylamino)-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(4,4,4-trifluorobutoxy)benzamide
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[F:1][C:2]([F:33])([F:32])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:31]=[CH:30][C:10]([C:11]([NH:13][CH:14]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=2)[C:15](O)=[O:16])=[O:12])=[CH:9][CH:8]=1.[CH3:34][NH2:35]>>[CH3:34][NH:35][C:15](=[O:16])[CH:14]([NH:13][C:11](=[O:12])[C:10]1[CH:30]=[CH:31][C:7]([O:6][CH2:5][CH2:4][CH2:3][C:2]([F:33])([F:32])[F:1])=[CH:8][CH:9]=1)[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=1참가 물질
3
실험 절차
A reaction similar to that described in Example 32 (32c) was conducted using 2-{[4-(4,4,4-trifluorobutoxy)benzoyl]amino}-3-[4-(trifluoromethoxy)phenyl]propanoic acid (360 mg) prepared in Example 82 (82a) and methylamine (450 μL, 2 M methanol solution) to give 270 mg of the title compound (white powder).
후처리
- customA reaction similar to
출처 및 근거
- ORD 기록
- ord-f82247bae0014789ad4ef7b1c346f4d8
- 출처 데이터셋
- uspto-grants-2013_01
- 특허 번호
- US08344029B2
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