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2-Amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride → 2-{[2-Fluoro-4-(3,3,3-trifluoropropoxy)benzoyl]amino}-3-[4-(trifluoromethoxy)phenyl]propanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride | HCID 22603340 | — |
| 反応物 | 2-Fluoro-4-(3,3,3-trifluoropropoxy)benzoic acid | HCID 69019004 | — |
| 生成物 | 2-{[2-Fluoro-4-(3,3,3-trifluoropropoxy)benzoyl]amino}-3-[4-(trifluoromethoxy)phenyl]propanoic acid | HCID 87657675 | 93.7% |
反応手順
A reaction similar to that described in Example 70 (70a) was conducted using 2-fluoro-4-(3,3,3-trifluoropropoxy)benzoic acid (177 mg) prepared in Example 84 (84a) and 2-amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride (200 mg) prepared in Reference Example 2 to give 317 mg of the title compound (white powder).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08344029B2 |
| 出典データセット | uspto-grants-2013_01 |
| ORD ID | ord-16f7d383c3bd46be9e793895133f6427 |
| 出典メモ | uspto-grants-2013_01 |