Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 11739881 | HCID 11739881 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Catalyst | Molybdenum carbonyl (Mo(CO)6) | HCID 98885 | — |
| Catalyst | trans-Bis(acetato)bis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium(II) | HCID 11104995 | — |
| Product | HCID 59516062 | HCID 59516062 | — |
Reaction Steps
1-(4-chlorophenyl)-N-cyclohexyl-N-methyl-5-propyl-pyrazole-4-carboxamide (Intermediate #24), 101 mg, 0.28 mmol), Molybdenum hexacarbonyl (37 mg, 0.14 mmol), Herrmann's catalyst (Trans-Di-Mu-Acetatobis[2-(Di-O-Tolylphosphino)Benzyl]dipalladium(II), 14 mg, 0.01 mmol), DMAP (69 mg, 0.56 mmol), DIPEA (98 μL, 0.56 mmol), Fu's salt (Tri-(T-Butyl)Phosphonium Hydrogen tetrafluoroborate Salt, 17 mg, 0.06 mmol), Dioxane (2 mL), Ethanol (2 mL) were mixed into to a microwave tube. The reaction mixture was then heated at 150° C. for 1 hour by microwave.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08344016B2 |
|---|
| Source dataset | uspto-grants-2013_01 |
|---|
| ORD ID | ord-8f67f0da62f3490ca9f988b55846095a |
|---|
| Source note | uspto-grants-2013_01 |
|---|
