HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1799423Generated: October 31, 2026
2-Aminoadamantane hydrochloride → Methyl 4-[4-(2-adamantylcarbamoyl)-5-cyclopentylsulfanyl-pyrazol-1-yl]benzoate
https://huagongshe.com/reaction/1799423
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Aminoadamantane hydrochloride | HCID 25331 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 5-Cyclopentylsulfanyl-1-(4-methoxycarbonylphenyl)pyrazole-4-carboxylic acid | HCID 59516110 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 4-[4-(2-adamantylcarbamoyl)-5-cyclopentylsulfanyl-pyrazol-1-yl]benzoate | HCID 59516124 | — |
Reaction Steps
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (199 mg, 1.04 mmol) was added in one portion to 5-(cyclopentylthio)-1-(4-(methoxycarbonyl)phenyl)-1H-pyrazole-4-carboxylic acid (Intermediate #93) (300 mg, 0.87 mmol), 2-Adamantanamine hydrochloride (179 mg, 0.95 mmol), 1-Hydroxybenzotriazole (140 mg, 1.04 mmol) and N-Ethyldiisopropylamine (0.450 mL, 2.60 mmol) in DMF (7 mL) at 20° C. under nitrogen. The resulting mixture was stirred at 20° C. for 18 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08344016B2 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-41ee18f2aad74c68bd7bcbf862b767a5 |
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| Source note | uspto-grants-2013_01 |
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