Methyl 4-[5-chloro-4-(cyclohexylcarbamoyl)pyrazol-1-yl]benzoate → Methyl 4-[5-cycloheptylsulfanyl-4-(cyclohexylcarbamoyl)pyrazol-1-yl]benzoate

HRID 1799427Notes

Reaction equation

HRID 1799427 reaction equation
Cl[C:2]1N(C2C=CC(C(OC)=O)=CC=2)N=C[C:3]=1C(=O)NC1CCCCC1.[CH:26]1([NH:32][C:33]([C:35]2[CH:36]=[N:37][N:38]([C:46]3[CH:55]=[CH:54][C:49]([C:50]([O:52][CH3:53])=[O:51])=[CH:48][CH:47]=3)[C:39]=2[S:40][CH:41]2[CH2:45][CH2:44][CH2:43][CH2:42]2)=[O:34])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[CH:41]1([S:40][C:39]2[N:38]([C:46]3[CH:55]=[CH:54][C:49]([C:50]([O:52][CH3:53])=[O:51])=[CH:48][CH:47]=3)[N:37]=[CH:36][C:35]=2[C:33](=[O:34])[NH:32][CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[CH2:42][CH2:43][CH2:3][CH2:2][CH2:44][CH2:45]1

Participants

3

Reactant 2

HCID 57437896Methyl 4-[5-chloro-4-(cyclohexylcarbamoyl)pyrazol-1-yl]benzoate2×HCID 59516142Methyl 4-[4-(cyclohexylcarbamoyl)-5-cyclopentylsulfanyl-pyrazol-1-yl]benzoate

Product 1

HCID 59516140Methyl 4-[5-cycloheptylsulfanyl-4-(cyclohexylcarbamoyl)pyrazol-1-yl]benzoate

Procedure

Methyl 4-[5-cycloheptylsulfanyl-4-(cyclohexylcarbamoyl)pyrazol-1-yl]benzoate was prepared from cycloheptylthiol and methyl 4-[5-chloro-4-(cyclohexylcarbamoyl)pyrazol-1-yl]benzoate (Intermediate #15) by the same process used for Intermediate #96.

Sources & evidence

ORD record
ord-b5f1dc3184b1495b995fa415d8624c27
Source dataset
uspto-grants-2013_01
Patent number
US08344016B2

Reaction notes

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