4-Chloro-3-(trifluoromethyl)phenylhydrazine hydrochloride → HCID 59516093, compound

HRID 1799435Notes

Reaction equation

HRID 1799435 reaction equation
C[N:2](/[CH:4]=[C:5](/[C:11](=O)[C:12]([CH3:15])([CH3:14])[CH3:13])\[C:6]([O:8][CH2:9][CH3:10])=[O:7])C.Cl.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25]N)=[CH:21][C:20]=1[C:27]([F:30])([F:29])[F:28].C(C1N(C2C=CC(Cl)=CC=2C)N=CC=1C(OCC)=O)(C)(C)C>>[C:12]([C:11]1[N:25]([C:22]2[CH:23]=[CH:24][C:19]([Cl:18])=[C:20]([C:27]([F:30])([F:28])[F:29])[CH:21]=2)[N:2]=[CH:4][C:5]=1[C:6]([O:8][CH2:9][CH3:10])=[O:7])([CH3:15])([CH3:14])[CH3:13]

Participants

4

Reactant 3

HCID 27818644-Chloro-3-(trifluoromethyl)phenylhydrazine hydrochlorideHCID 14003880(Z)-ethyl 2-((dimethylamino)methylene)-4,4-dimethyl-3-oxopentanoate2×HCID 59516082ethyl 5-tert-butyl-1-(4-chloro-2-methylphenyl)-1H-pyrazole-4-carboxylate

Product 1

HCID 59516093HCID 59516093, compound

Procedure

Ethyl 5-tert-butyl-1-(4-chloro-3-(trifluoromethyl)phenyl)-1H-pyrazole-4-carboxylate was prepared from (Z)-ethyl 2-((dimethylamino)methylene)-4,4-dimethyl-3-oxopentanoate (Intermediate #83) and (4-chloro-3-(trifluoromethyl)phenyl)hydrazine hydrochloride by the same process used for Intermediate #116.

Sources & evidence

ORD record
ord-37de3485b99845959ef1e4565b13c55d
Source dataset
uspto-grants-2013_01
Patent number
US08344016B2

Reaction notes

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