Triethylamine → HCID 59615715, compound

Participants

Reaction Steps

As shown in step 2-iii of Scheme 2, compound 1004 (91 mg, 0.423 mmol), 1,1′-carbonyldiimidazole (103 mg, 0.634 mmol), and triethylamine (85.6 mg, 0.845 mmol) were stirred in 2.1 mL of DMF at 60° C. for 2 hours. After this time, MTBE was added and the resulting precipitate collected by filtration to produce N-(4-methyl-5-(pyridin-3-ylethynyl)thiazol-2-yl)-1H-imidazole-1-carboxamide (compound 1005, 120 mg), which was immediately used in subsequent reactions as is.

Provenance & Evidence