m-Chloroperbenzoic acid → Methyl 2-methylnicotinate 1-oxide

HRID 1799542노트

반응식

HRID 1799542 반응식
[CH3:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.C1C=C(Cl)C=C(C(OO)=[O:20])C=1>C(Cl)Cl>[CH3:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=[CH:4][N+:3]=1[O-:20]

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 7015327Methyl 2-methylnicotinate

생성물 1

HCID 20163965Methyl 2-methylnicotinate 1-oxide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Methyl 2-methylpyridine-3-carboxylate (10 g, 66.2 mmol) was taken up in DCM (140 mL) and mCPBA (16.31 g, 72.8 mmol) was added. The resulting solution was stirred at room temperature overnight. The reaction mixture was purified directly by silica gel chromatography (0-20% MeOH/EtOAc) to afford the title compound as a beige solid.

후처리

  1. customThe reaction mixture was purified directly by silica gel chromatography (0-20% MeOH/EtOAc)

출처 및 근거

ORD 기록
ord-5826699f908e498497767f14fa30e8d5
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08344144B2

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