m-Chloroperbenzoic acid → 2-(Chloromethyl)-3-(methoxycarbonyl)pyridine 1-oxide

関与物質

反応手順

Methyl 2-(chloromethyl)pyridine-3-carboxylate (4.45 g, 23.98 mmol) was taken up in DCM (50 mL) and mCPBA (5.91 g, 26.4 mmol) was added. The resulting solution was stirred at room temperature overnight. The reaction mixture was then purified directly by silica gel chromatography (0-20% MeOH/EtOAe) to give methyl 2-(chloromethyl)pyridine-3-carboxylate 1-oxide as a white solid.

情報源と証拠