HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 6-Chloro-3-methylpyridine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 2-Cyano-3-methylpyridine 1-oxide | HCID 45079822 | — |
| Product | 6-Chloro-3-methylpyridine-2-carbonitrile | HCID 46856278 | — |
Reaction Steps
3-Methylpyridine-2-carbonitrile 1-oxide (8.42 g, 62.8 mmol) was stirred in refluxing POCl3 (60 mL, 646 mmol) for 6 hours. The mixture was cooled to room temperature and slowly poured into ice-water. The resulting beige precipitate was collected by filtration to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08344144B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-bae3a1eea51b45be8ab5aab6641cd751 |
| Source note | uspto-grants-2013_01 |