Azobisisobutyronitrile → 2-Pyridinecarboxylic acid, 3-(bromomethyl)-6-chloro-, methyl ester

Participants

Reaction Steps

Methyl 6-chloro-3-methylpyridine-2-carboxylate (3.46 g, 18.6 mmol), NBS (3.32 g, 18.6 mmol) and AIBN (61 mg, 0.37 mmol) were stirred in refluxing CCl4 (40 mL) for 6 hours. The mixture was then cooled to room temperature and purified directly by silica gel chromatography (2-20% EtOAc/hexanes) to give the title compound as a white solid.

Provenance & Evidence