HCID 58216621, compound → HCID 44554810, compound

HRID 1799563Notes

Reaction equation

HRID 1799563 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:23]1[N:28]=[C:27]2[N:29]=[C:30]([CH2:39][N:40]3[CH2:45][CH2:44][O:43][CH2:42][CH2:41]3)[N:31](C(OC(C)(C)C)=O)[C:26]2=[CH:25][CH:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[N:28]=[C:27]3[N:29]=[C:30]([CH2:39][N:40]4[CH2:45][CH2:44][O:43][CH2:42][CH2:41]4)[NH:31][C:26]3=[CH:25][CH:24]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

3

Reactant 2

HCID 58216621HCID 58216621, compoundHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 44554810HCID 44554810, compound

Procedure

The title compound was prepared as described in Example 1 Step 5 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (300 mg, 0.96 mmol) and tert-butyl 5-chloro-2-(morpholin-4-ylmethyl)-1H-imidazo[4,5-b]pyridine-1-carboxylate (340 mg, 0.96 mmol) as starting materials.

Sources & evidence

ORD record
ord-13a98491f3a34d29b567dc29c2023d14
Source dataset
uspto-grants-2013_01
Patent number
US08344144B2

Reaction notes

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