Water → 6-Methoxy-2-methyl-3-nitropyridine

HRID 1799570Notes

Reaction equation

HRID 1799570 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][CH:3]=1.[CH3:12][O-:13].[Na+].O>CO>[CH3:12][O:13][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 2531236-Chloro-2-methyl-3-nitropyridineHCID 10942334Sodium Methoxide

Product 1

HCID 2304756-Methoxy-2-methyl-3-nitropyridine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A roundbottom flask was charged with a solution of 6-chloro-2-methyl-3-nitropyridine (12.0 g, 69.36 mmol) in methanol (100 ml). Sodium methanolate (5.6 g, 103.70 mmol) was added and the resulting solution was stirred at room temperature for 24 hours. The mixture was poured into 100 ml of water and the solids that formed were collected by filtration to afford the title compound.

Workup

  1. customthe solids that formed
  2. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-4e8378fd464a47fdb032d011c24f45bc
Source dataset
uspto-grants-2013_01
Patent number
US08344144B2

Reaction notes

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