HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-[4-(1-Hydroxy-1-methylethyl)phenyl]-2-[(6-methoxy-1,5-naphthyridin-2-yl)amino]thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl | HCID 11155794 | — |
| Reactant | 2-Bromo-6-methoxy-1,5-naphthyridine | HCID 58216651 | — |
| Reactant | 2-Amino-5-[4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 59526212 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Product | 5-[4-(1-Hydroxy-1-methylethyl)phenyl]-2-[(6-methoxy-1,5-naphthyridin-2-yl)amino]thiophene-3-carboxamide | HCID 44555128 | — |
Reaction Steps
The title compound was prepared according to the general procedure in Example 30 (Method B) using 2-bromo-6-methoxy-1,5-naphthyridine (54 mg, 0.22 mmol), 2-amino-5-[4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (60 mg, 0.20 mmol), potassium carbonate (31 mg, 0.22 mmol), X-Phos (49 mg, 0.10 mmol), and tris(dibenzylideneacetone)dipalladium (16 mg, 0.02 mmol) as the starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08344144B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-64fc27bc05be44fa8a78d89842dfa7ac |
| Source note | uspto-grants-2013_01 |