6-Chloro-3-nitropyridin-2-ylamine → HCID 85766671, compound

Participants

Reaction Conditions

Reaction Steps

6-Chloro-3-nitropyridin-2-amine (1.25 g, 7.06 mmol) and iodobenzene diacetate (5.80 g, 17.65 mmol) were taken-up in acetone (70.6 ml) and stirred at 80° C. for 6 hours. The reaction was then concentrated directly, and the resulting crude product was purified by silica gel chromatography (0-100% ethyl acetate/hexanes) to afford 5-chloro[1,2,5]oxadiazolo[3,4-b]pyridine 1-oxide. LRMS (APCI) calc'd for (C5H3ClN3O2) [M+H]+, 172. found 172.

Provenance & Evidence