HCID 319582, compound → HCID 44553094, compound

HRID 1799594Notes

Reaction equation

HRID 1799594 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:23]1[CH:24]=[CH:25][C:26]2[C:27](=[N:29][S:30][N:31]=2)[N:28]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[CH:24]=[CH:25][C:26]3[C:27](=[N:29][S:30][N:31]=3)[N:28]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

3

Reactant 2

HCID 319582HCID 319582, compoundHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 44553094HCID 44553094, compound

Procedure

The title compound was prepared as described in Example 1, Step 5 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.48 mmol) and 5-chloro[1,2,5]thiadiazolo[3,4-b]pyridine (82 mg, 0.48 mmol) as starting materials. LRMS (APCI) calc'd for (C19H16F2N5O2S2) [M+H]+, 448. found 448.

Sources & evidence

ORD record
ord-3de5ff3edfb84b2ba893da6512106f5a
Source dataset
uspto-grants-2013_01
Patent number
US08344144B2

Reaction notes

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