Phenol → (R)-4-dimethylamino-3-[9-phenoxy-nonanoylamino]-butyric acid benzyl ester

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Reaction Steps

The title compound, m/e=379.4 ([M+H]+), was produced in analogy with example 18, steps 1 to 4. Thus, phenol was alkylated in step 1 with 9-bromo-1-nonanol, leading to 9-phenoxy-nonan-1-ol, which was oxidized in step 2 to 9-phenoxy-nonanoic acid. This was coupled in step 3 with (R)-3-amino-4-dimethylamino-butyric acid benzyl ester dihydrochloride to produce (R)-4-dimethylamino-3-[9-phenoxy-nonanoylamino]-butyric acid benzyl ester, which was hydrogenated in step 4.

Provenance & Evidence