HCID 44482119, compound → HCID 44479290, compound

HRID 1799649Notes

Reaction equation

HRID 1799649 reaction equation
C([O:8][C:9](=[O:34])[CH2:10][C@@H:11]([NH:16][C:17](=[O:33])[CH2:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:12][N:13]([CH3:15])[CH3:14])C1C=CC=CC=1.CN(C)C[C@H](NC(=O)CCCCCCCCOC1C=CC=CC=1F)CC(O)=O>>[CH3:15][N:13]([CH3:14])[CH2:12][C@H:11]([NH:16][C:17](=[O:33])[CH2:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[CH2:10][C:9]([OH:34])=[O:8]

Participants

3

Reactant 2

HCID 44482119HCID 44482119, compoundHCID 66874651HCID 66874651, compound

Product 1

HCID 44479290HCID 44479290, compound

Procedure

Hydrogenation of (R)-4-dimethylamino-3-[4-(5-phenyl-pentyloxy)-butyrylamino]-butyric acid benzyl ester in analogy with example 1, step 4 produced (R)-4-dimethylamino-3-[9-(2-fluoro-phenoxy)-nonanoylamino]-butyric acid. White solid, m/e=379.5 ([M+H]+).

Sources & evidence

ORD record
ord-6d81054ceede4b2785c5f2aaf33148c2
Source dataset
uspto-grants-2013_01
Patent number
US08344027B2

Reaction notes

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