1,6-Hexanediol → HCID 66874516, compound

Participants

Reaction Steps

The title compound, m/e=379.4 ([M+H]+), was produced in analogy with example 1, steps 1 to 4. Thus, 1,6-hexanediol was alkylated in step 1 with 1-bromo-3-phenylpropane, leading to 6-(3-phenyl-propoxy)-hexan-1-ol, which was oxidized in step 2 to 6-(3-phenyl-propoxy)-hexanoic acid. This was coupled in step 3 with (R)-3-amino-4-dimethylamino-butyric acid benzyl ester dihydrochloride to produce (R)-4-dimethylamino-3-[6-(3-phenyl-propoxy)-hexanoylamino]-butyric acid benzyl ester, which was hydrogenated in step 4.

Provenance & Evidence