Benzyl mercaptan → HCID 68993960, compound

Participants

Reaction Steps

The title compound, m/e=427.4 ([M+H]+), was produced in analogy with example 59, steps 1 to 5. Thus, phenyl-methanethiol was alkylated in step 1 with 8-bromo-1-octanol, leading to 8-benzylsulfanyl-octan-1-ol, which was oxidized in step 2 to 8-phenylmethanesulfonyl-octan-1-ol. This was oxidized in step 3 to 8-phenylmethanesulfonyl-octanoic acid, then coupled in step 4 with (R)-3-amino-4-dimethylamino-butyric acid benzyl ester dihydrochloride to produce (R)-4-dimethylamino-3-(8-(phenylmethanesulfonyl)-octanoylamino)-butyric acid benzyl ester, which was hydrogenated in step 5.

Provenance & Evidence