HCID 44479791, compound → HCID 44479793, compound

HRID 1799667Notes

Reaction equation

C([O:8][C:9](=[O:35])[CH2:10][C@@H:11]([NH:16][C:17](=[O:34])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][N:26]([CH3:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:12][N:13]([CH3:15])[CH3:14])C1C=CC=CC=1.CN(C)C[C@H](NC(=O)CCCCCCCCN(C)CCC1C=CC=CC=1)CC(O)=O>>[CH3:15][N:13]([CH3:14])[CH2:12][C@H:11]([NH:16][C:17](=[O:34])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][N:26]([CH3:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:10][C:9]([OH:35])=[O:8]

Participants

Reactant 2

HCID 44479791HCID 44479791, compound

HCID 66875150HCID 66875150, compound

Product 1

HCID 44479793HCID 44479793, compound

Procedure

Hydrogenation of (R)-4-dimethylamino-3-[9-(methyl-phenyl-amino)-nonanoylamino]-butyric acid benzyl ester in analogy with example 1, step 4 produced (R)-4-dimethylamino-3-[9-(methyl-phenethyl-amino)-nonanoylamino]-butyric acid. White solid, m/e=392.3 ([M+H]+).

Sources & evidence

ORD record: ord-b7c34c2eaf414d99aa366aa31191aec0
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08344027B2

Reaction notes

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