Azetidine hydrochloride → HCID 68599820, compound

HRID 1799684Notes

Reaction equation

[C:1]([C:4]1[N:5]=[CH:6][S:7][C:8]=1/[CH:9]=[CH:10]\[S:11][C:12]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(O)=[O:2].Cl.[NH:32]1[CH2:35][CH2:34][CH2:33]1>>[N:32]1([C:1]([C:4]2[N:5]=[CH:6][S:7][C:8]=2/[CH:9]=[CH:10]\[S:11][C:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)=[O:2])[CH2:35][CH2:34][CH2:33]1

Participants

Reactant 2

HCID 12308726Azetidine hydrochloride

HCID 68601215HCID 68601215, compound

Product 1

HCID 68599820HCID 68599820, compoundYield 84.5%

Procedure

In the same manner as in step c) in Example 3, 594 mg of the title compound was prepared from 644 mg of 4-carboxy-5-((Z)-2-tritylthioethen-1-yl)thiazole and 168 mg of azetidine hydrochloride.

Sources & evidence

ORD record: ord-89aa2d2516b04fedb526b43d37742e4c
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08344154B2

Reaction notes

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