1,3-Propanediol → HCID 68600542, compound

HRID 1799686Notes

Reaction equation

HRID 1799686 reaction equation
Cl[CH2:2][C:3]1[N:4]=[CH:5][S:6][C:7]=1/[CH:8]=[CH:9]\[S:10][C:11]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[CH2:30]([OH:34])[CH2:31][CH2:32][OH:33]>>[OH:33][CH2:32][CH2:31][CH2:30][O:34][CH2:2][C:3]1[N:4]=[CH:5][S:6][C:7]=1/[CH:8]=[CH:9]\[S:10][C:11]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 104421,3-PropanediolHCID 68601237HCID 68601237, compound

Product 1

HCID 68600542HCID 68600542, compound

Procedure

In the same manner as in step b) in Example 2, 674 mg of the title compound was prepared from 665 mg of 4-chloromethyl-5-((Z)-2-tritylthioethen-1-yl)thiazole prepared in step a) in Example 2 and 3 ml of 1,3-propanediol.

Sources & evidence

ORD record
ord-e90a67e07d18403a9066a9f781b63720
Source dataset
uspto-grants-2013_01
Patent number
US08344154B2

Reaction notes

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