Ammonia dioxane → HCID 86609813, compound

HRID 1799688Notes

Reaction equation

[NH2:1][C:2]1[S:3][C:4](/[CH:12]=[CH:13]\[S:14][C:15]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:5]([C:7](OCC)=[O:8])[N:6]=1.[NH3:34].O1CCOCC1>>[NH2:1][C:2]1[S:3][C:4](/[CH:12]=[CH:13]\[S:14][C:15]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:5]([C:7](=[O:8])[NH2:34])[N:6]=1

Participants

Reactant 2

HCID 66648793Ammonia dioxane

HCID 86609814HCID 86609814, compound

Product 1

HCID 86609813HCID 86609813, compound

Procedure

In the same manner as in step b) in Example 3 and step c) in Example 3, 197 mg of the title compound was prepared from 501 mg of 2-amino-4-ethoxycarbonyl-5-((Z)-2-tritylthioethen-1-yl)thiazole and 8 ml of a 0.5 M ammonia/dioxane solution.

Sources & evidence

ORD record: ord-12d8a6def68144059341795a0d4962a4
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08344154B2

Reaction notes

Loading…