HCID 66916281, compound → HCID 68601979, compound

HRID 1799690Notes

Reaction equation

HRID 1799690 reaction equation
[C:1]([C:4]1[N:5]=[C:6](/[CH:9]=[CH:10]\[S:11][C:12]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[S:7][CH:8]=1)(O)=[O:2].C(C(C(C(O)=O)O)O)(O)=O.[OH:41][CH:42]1[CH2:45][NH:44][CH2:43]1>>[OH:41][CH:42]1[CH2:45][N:44]([C:1]([C:4]2[N:5]=[C:6](/[CH:9]=[CH:10]\[S:11][C:12]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[S:7][CH:8]=2)=[O:2])[CH2:43]1

Participants

3

Reactant 2

HCID 66916281HCID 66916281, compoundHCID 68599559HCID 68599559, compound

Product 1

HCID 68601979HCID 68601979, compoundYield 79.7%

Procedure

In the same manner as in step c) in Example 3, 1.169 g of the title compound was prepared from 1.300 g of 4-carboxy-2-((Z)-2-tritylthioethen-1-yl)thiazole and 1.028 g of 3-hydroxyazetidine tartrate.

Sources & evidence

ORD record
ord-08247fa028b1458a892f95edb00ac82e
Source dataset
uspto-grants-2013_01
Patent number
US08344154B2

Reaction notes

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