Azetidine-3-carbonitrile hydrochloride → HCID 68600715, compound

HRID 1799691Notes

Reaction equation

HRID 1799691 reaction equation
[C:1]([C:4]1[N:5]=[C:6](/[CH:9]=[CH:10]\[S:11][C:12]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[S:7][CH:8]=1)([OH:3])=O.Cl.[C:32]([CH:34]1[CH2:37][NH:36][CH2:35]1)#[N:33]>>[C:32]([CH:34]1[CH2:37][N:36]([C:1]([C:4]2[N:5]=[C:6](/[CH:9]=[CH:10]\[S:11][C:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[S:7][CH:8]=2)=[O:3])[CH2:35]1)#[N:33]

Participants

3

Reactant 2

HCID 45072465Azetidine-3-carbonitrile hydrochlorideHCID 68599559HCID 68599559, compound

Product 1

HCID 68600715HCID 68600715, compoundYield 66.2%

Procedure

In the same manner as in step c) in Example 3, 0.271 g of the title compound was prepared from 0.356 g of 4-carboxy-2-((Z)-2-tritylthioethen-1-yl)thiazole and 0.149 g of 3-cyanoazetidine hydrochloride.

Sources & evidence

ORD record
ord-5de9dc112a31445ba8969469469bbf5b
Source dataset
uspto-grants-2013_01
Patent number
US08344154B2

Reaction notes

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