HCID 66997759, compound → HCID 66996881, compound

HRID 17997Notes

Reaction equation

HRID 17997 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][C:30]=1[F:31])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([O:25][CH3:26])[C:10](=[O:24])[N:11]3[CH2:21][CH2:20][CH2:19][CH2:18][N:17]([CH3:22])[C:16](=[O:23])[C:12]3=2)[C:7]1=[O:27].[H][H]>[Pd].C(O)C>[F:31][C:30]1[CH:2]=[CH:3][C:4]([CH2:5][N:6]2[CH2:15][CH2:14][C:13]3[C:8](=[C:9]([O:25][CH3:26])[C:10](=[O:24])[N:11]4[CH2:21][CH2:20][CH2:19][CH2:18][N:17]([CH3:22])[C:16](=[O:23])[C:12]4=3)[C:7]2=[O:27])=[CH:28][CH:29]=1

Participants

5

Reactant 2

HCID 66997759HCID 66997759, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 66996881HCID 66996881, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 11-(3-chloro-4-fluorobenzyl)-9-methoxy-2-methyl-3,4,5,6,12,13-hexahydro-2H[1,4]diazocino[2,1-a]-2,6-naphthyridine-1,8,10(11H)-trione (52 mg, 0.12 mmol) and 10% palladium on charcoal (70 mg) in ethanol (6 mL) was stirred at room temperature under a balloon of hydrogen overnight. The reaction mixture was filtered and concentrated under vacuum. ES MS M+1=480

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-535fc9cea9c34e0ab036ae180e6921af
Source dataset
uspto-grants-2010_06
Patent number
US07741315B2

Reaction notes

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