HuagongsheHuagongshe Chemistry Print Report · For research reference only
1(3H)-Isobenzofuranone, 3-bromo- → HCID 131728005, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1(3H)-Isobenzofuranone, 3-bromo- | HCID 96218 | — |
| Reactant | Sodium (1r,5s,6s)-6-((1r)-1-hydroxyethyl)-2-[[(z)-2-(4-hydroxymethyl-thiazol-5-yl)ethen-1-yl]thio]-1-methyl-1-carbapen-2-em-3-carboxylate | HCID 23676797 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 131728005 | HCID 131728005 | 59.2% |
Reaction Steps
The title compound (122 mg) was prepared from 162 mg of sodium (1R,5S,6S)-6-((1R)-1-hydroxyethyl)-2-[[(Z)-2-(4-hydroxymethylthiazol-5-yl)ethen-1-yl]thio]-1-methyl-1-carbapen-2-em-3-carboxylate and 128 mg of 3-bromophthalide in the same manner as in Example 81, except that only DMA was used as the solvent and the reaction was carried out at room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08344154B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-8544d86fe32d4ffe8b75e40b7b9e0c8e |
| Source note | uspto-grants-2013_01 |