1-Isopropylhydrazine hydrochloride → HCID 58204990, compound

HRID 1800069Notes

Reaction equation

HRID 1800069 reaction equation
[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[C:6]3[N:10]([CH2:11][CH2:12][O:13][C:4]=2[CH:3]=1)[CH:9]=[C:8]([C:14]([NH:16][C:17](=[NH:20])[S:18][CH3:19])=O)[N:7]=3.Cl.[CH:24]([NH:27]N)([CH3:26])[CH3:25]>C(O)(=O)C>[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[C:6]3[N:10]([CH:9]=[C:8]([C:14]4[N:27]([CH:24]([CH3:26])[CH3:25])[N:20]=[C:17]([S:18][CH3:19])[N:16]=4)[N:7]=3)[CH2:11][CH2:12][O:13][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 855731-Isopropylhydrazine hydrochlorideHCID 140563933HCID 140563933, compound

Product 1

HCID 58204990HCID 58204990, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1-(8-Bromo-4,5-dihydro-6-oxa-1,3a-diaza-benzo[e]azulene-2-carbonyl)-2-methyl-isothiourea (27 mg, 0.068 mmol) was heated with isopropylhydrazine hydrochloride (23 mg, 0.20 mmol) in acetic acid (0.9 mL) at 100° C. overnight. The mixture was concentrated and the crude residue purified by reverse-phase HPLC to give 240. LCMS EI: 422.1

Workup

  1. concentrationThe mixture was concentrated
  2. customthe crude residue purified by reverse-phase HPLC

Sources & evidence

ORD record
ord-4deb95c15d704928bbb7063618261918
Source dataset
uspto-grants-2013_01
Patent number
US08343955B2

Reaction notes

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