HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → 5-(9-(5-fluoropyridin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-1-isopropyl-1H-1,2,4-triazol-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | HCID 16414268 | — |
| Reactant | 5-(8-Bromo-4,5-dihydro-6-oxa-1,3a-diaza-benzo[e]azulen-2-yl)-1-isopropyl-1H-[1,2,4]triazol-3-ylamine | HCID 58204439 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 5-(9-(5-fluoropyridin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-1-isopropyl-1H-1,2,4-triazol-3-amine | HCID 58204880 | — |
Reaction Steps
5-(8-Bromo-4,5-dihydro-6-oxa-1,3a-diaza-benzo[e]azulen-2-yl)-1-isopropyl-1H-[1,2,4]triazol-3-ylamine was reacted with 3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine were reacted under Suzuki palladium coupling conditions. The crude product was purified by reverse phase HPLC to give 241. LCMS: 406.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08343955B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-a9f78a6631904fbb8765926062e7d8cc |
| Source note | uspto-grants-2013_01 |