(2S)-N-methylpyrrolidine-2-carboxamide → HCID 58204750, compound

HRID 1800238Notes

Reaction equation

HRID 1800238 reaction equation
FC(F)(F)S(O[C:7]1[N:28]=[CH:27][C:10]2[C:11]3[N:12]([CH:16]=[C:17]([C:19]4[N:23]([CH:24]([CH3:26])[CH3:25])[N:22]=[CH:21][N:20]=4)[N:18]=3)[CH2:13][CH2:14][O:15][C:9]=2[CH:8]=1)(=O)=O.[CH3:31][NH:32][C:33]([C@@H:35]1[CH2:39][CH2:38][CH2:37][NH:36]1)=[O:34]>>[CH:24]([N:23]1[C:19]([C:17]2[N:18]=[C:11]3[C:10]4[CH:27]=[N:28][C:7]([N:36]5[CH2:37][CH2:38][CH2:39][C@H:35]5[C:33]([NH:32][CH3:31])=[O:34])=[CH:8][C:9]=4[O:15][CH2:14][CH2:13][N:12]3[CH:16]=2)=[N:20][CH:21]=[N:22]1)([CH3:25])[CH3:26]

Participants

3

Reactant 2

HCID 10374482(2S)-N-methylpyrrolidine-2-carboxamideHCID 58204987HCID 58204987, compound

Product 1

HCID 58204750HCID 58204750, compound

Procedure

Following the procedures of Example 388, 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl trifluoromethanesulfonate and (S)—N-methylpyrrolidine-2-carboxamide were reacted to give 405. M/z 423.2, calc. 422.22. 1H NMR (400 MHz, DMSO) δ 9.06 (s, 1H), 7.88 (s, 1H), 7.83 (s, 1H), 7.74 (d, J=4.3, 1H), 5.95 (p, J=6.7, 2H), 4.58-4.41 (m, 4H), 4.35 (d, J=8.5, 1H), 3.67-3.57 (m, 1H), 3.41-3.33 (m, 1H), 2.57 (d, J=4.6, 3H), 2.15 (dd, J=10.8, 7.7, 1H), 1.94 (d, J=6.6, 3H), 1.47 (dd, J=6.6, 2.4, 6H)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-a41de707683045a186f5920bdde937fe
Source dataset
uspto-grants-2013_01
Patent number
US08343955B2

Reaction notes

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