Tert-butyl {4-methyl-3-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate → Tert-butyl {3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}carbamate

HRID 1800411노트

반응식

HRID 1800411 반응식
[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([O:15][C:16]2[CH:17]=[N:18][C:19]([N+:22]([O-])=O)=[CH:20][CH:21]=2)[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[C].[Pd]>[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([O:15][C:16]2[CH:17]=[N:18][C:19]([NH2:22])=[CH:20][CH:21]=2)[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 1

HCID 57749145Tert-butyl {4-methyl-3-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate

생성물 1

HCID 57749176Tert-butyl {3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}carbamate수율 100.2%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

To a solution of tert-butyl{4-methyl-3-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate (1.85 g, 5.35 mmol) in methanol (10 mL) was added palladium carbon (50% water-containing product, 100 mg), and the mixture was stirred at room temperature for 3 hr under a hydrogen atmosphere of 1.0 pressure. The reaction mixture was filtered through celite, the filtrate was concentrated under reduced pressure, and the residue was dried to give the title compound (1.69 g, 99%) as a colorless oil.

후처리

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customthe residue was dried

출처 및 근거

ORD 기록
ord-a6990a0eed0643df8140e6bcedc7d558
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08344135B2

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