Dimethylformamide → 3-(1-Cyano-1-methylethyl)benzoyl chloride

Participants

Reaction Steps

To a solution of 3-(1-cyano-1-methylethyl)benzoic acid (53 mg, 0.280 mmol) produced in Example B2(x) in tetrahydrofuran (2.0 mL) were added oxalyl chloride (35 μL, 0.42 mmol) and N,N-dimethylformamide (about 20 μL), and the mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated under reduced pressure to give 3-(1-cyano-1-methylethyl)benzoyl chloride as a pale-brown oil.

Provenance & Evidence