Dimethylformamide → 3-(1-Cyanocyclopropyl)benzoyl chloride

Participants

Reaction Steps

To a solution of 3-(1-cyanocyclopropyl)benzoic acid (139 mg, 0.742 mmol) produced in Example B3(ii) in tetrahydrofuran (7.0 mL) were added oxalyl chloride (80 μL, 0.929 mmol) and N,N-dimethylformamide (about 20 μL), and the mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated under reduced pressure to give 3-(1-cyanocyclopropyl)benzoyl chloride as a pale-brown oil.

Provenance & Evidence