Hydrochloric Acid → HCID 86645992, compound

Participants

Reaction Steps

To a solution of methyl 3-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-4-methoxybenzoate (4.0 g, 9.96 mmol) in methanol (50 mL)-tetrahydrofuran (100 mL) was added 5N aqueous sodium hydroxide solution (80 mL), and the mixture was stirred at room temperature for 3 hr. 6N Hydrochloric acid was added to the reaction solution to adjust the pH to about 4.0, and the reaction solution was extracted with ethyl acetate (200 mL×3). The combined organic layer was dried over anhydrous magnesium sulfate, the insoluble material was filtered off, and the filtrate was concentrated to give the title compound (3.70 g, 96%) as a yellow solid.

Provenance & Evidence