HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-(1-Cyano-1-methylethyl)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3-(2-Cyanopropan-2-yl)benzoic acid | HCID 57149538 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(1-Cyano-1-methylethyl)benzoyl chloride | HCID 86631981 | — |
Reaction Steps
To a solution of 3-(1-cyano-1-methylethyl)benzoic acid (4.2 g, 22.2 mmol) produced in Example C6(ii) in tetrahydrofuran (44 mL) were added oxalyl chloride (2.28 mL, 28.2 mmol) and N,N-dimethylformamide (20 μL), and the mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated under reduced pressure to give 3-(1-cyano-1-methylethyl)benzoyl chloride as a pale-yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08344135B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-66cd63cfba4b49a39455ba5ef4134e3e |
| Source note | uspto-grants-2013_01 |