反应详情

温度

70 °C

N-[4-Chloro-5-({2-[(chloroacetyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]-3-(1-cyano-1-methylethyl)benzamide synthesized above was dissolved in tetrahydrofuran (3.0 mL), triethylamine (128 μL, 0.933 mmol) and N-ethylpiperazine (118 μL, 0.933 mmol) were added, and the mixture was stirred at 70° C. for 4 hr. The reaction mixture was cooled to room temperature, diluted with ethyl acetate (10 mL), washed with water (10 mL) and saturated brine (10 mL), and dried over anhydrous sodium sulfate. The insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (ethyl acetate/methanol=100/0→85/15), and the obtained solution was concentrated under reduced pressure. The residue was triturated with ethyl acetate/hexane to give the title compound (133 mg, 67%) as a colorless powder.

1. temperatureThe reaction mixture was cooled to room temperature
2. washwashed with water (10 mL) and saturated brine (10 mL)
3. dry with materialdried over anhydrous sodium sulfate
4. filtrationThe insoluble material was filtered off
5. concentrationthe filtrate was concentrated under reduced pressure
6. customThe residue was purified by basic silica gel column chromatography (ethyl acetate/methanol=100/0→85/15)
7. concentrationthe obtained solution was concentrated under reduced pressure
8. customThe residue was triturated with ethyl acetate/hexane