Potassium Carbonate → HCID 18402987, compound

Participants

Reaction Steps

A mixture of 5-amino-2-chloro-4-fluorophenol (5.00 g, 30.9 mmol), 2-chloro-5-nitropyridine (5.09 g, 32.1 mmol), potassium carbonate (4.51 g, 32.6 mmol) and N,N-dimethylformamide (50 mL) was stirred at room temperature for 13 hr. To the reaction mixture was added aqueous ammonium chloride solution (50 mL), and the mixture was extracted with ethyl acetate (80 mL×3). The organic layer was washed with water (50 mL) and saturated brine (30 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The precipitate was collected by filtration to give the title compound (6.31 g, 72%) as a yellow powder.

Provenance & Evidence