Morpholine → HCID 59506920, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-[3-({2-[(chloroacetyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-4-methylphenyl]-3-(1-cyano-1-methylethyl)benzamide (304 mg, 0.584 mmol) produced in Example C15(i) in tetrahydrofuran (5 mL) were added morpholine (78.8 μL, 0.901 mmol) and triethylamine (125 μL, 0.901 mmol), and the mixture was stirred at 60° C. for 4 hr. The title compound (141 mg, 55%) was obtained as white crystals by operation in the same manner as in Example C88. The present compound was recrystallized from ethyl acetate and tetrahydrofuran.

Provenance & Evidence