HCID 67415648, compound → Di-tert-butyl (5-amino-2-fluorophenyl)imidodicarbonate

HRID 1800644Notes

Reaction equation

HRID 1800644 reaction equation
[C:1]([O:5][C:6]([N:8]([C:16]1[CH:21]=[C:20]([N+:22]([O-])=O)[CH:19]=[CH:18][C:17]=1[F:25])[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[C].[Pd]>[C:1]([O:5][C:6]([N:8]([C:16]1[CH:21]=[C:20]([NH2:22])[CH:19]=[CH:18][C:17]=1[F:25])[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 1

HCID 67415648HCID 67415648, compound

Product 1

HCID 67414473Di-tert-butyl (5-amino-2-fluorophenyl)imidodicarbonateYield 64%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

To a solution of di-tert-butyl(2-fluoro-5-nitrophenyl)imidodicarbonate (256 mg, 0.718 mmol) in methanol (10 mL) was added 10% palladium-carbon (50 mg), and the mixture was stirred under a hydrogen atmosphere at room temperature overnight. 10% Palladium-carbon powder was filtered off by celite filtration, and the filtrate was concentrated under reduced pressure to give the title compound (150 mg, 64%).

Workup

  1. filtration10% Palladium-carbon powder was filtered off by celite filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-5b1c987f3b8b4348bd1160aef848cff6
Source dataset
uspto-grants-2013_01
Patent number
US08344135B2

Reaction notes

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