HCID 58313095, compound → HCID 178502365, compound

HRID 1800805Notes

Reaction equation

[C:1]([N:4]1[C:8]2([CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH2:7][CH2:6][CH:5]1[C:14]([OH:16])=O)(=[O:3])[CH3:2].CC(C)[C@H](NC(OC)=O)C(N1C(C([NH:39][CH2:40][C:41]([C:43]2[CH:48]=[CH:47][C:46]([C:49]3[CH:54]=[CH:53][C:52]([C:55]4[N:56]=[C:57]([C@@H:60]5[CH2:64][CH2:63][CH2:62][N:61]5[C:65](=[O:75])[C@@H:66]([NH:70][C:71]([O:73][CH3:74])=[O:72])[CH:67]([CH3:69])[CH3:68])[NH:58][CH:59]=4)=[CH:51][CH:50]=3)=[CH:45][CH:44]=2)=[O:42])=O)CC2(CN(C(OC(C)(C)C)=O)C2)C1)=O>>[C:1]([N:4]1[C:8]2([CH2:9][CH2:10][O:11][CH2:12][CH2:13]2)[CH2:7][CH2:6][CH:5]1[C:14]([NH:39][CH2:40][C:41]([C:43]1[CH:48]=[CH:47][C:46]([C:49]2[CH:50]=[CH:51][C:52]([C:55]3[N:56]=[C:57]([C@@H:60]4[CH2:64][CH2:63][CH2:62][N:61]4[C:65]([C@@H:66]([NH:70][C:71](=[O:72])[O:73][CH3:74])[CH:67]([CH3:69])[CH3:68])=[O:75])[NH:58][CH:59]=3)=[CH:53][CH:54]=2)=[CH:45][CH:44]=1)=[O:42])=[O:16])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 58313095HCID 58313095, compound

HCID 178502284HCID 178502284, compound

Product 1

HCID 178502365HCID 178502365, compoundYield 67%

Procedure

This compound was prepared in an analogous fashion to 169 from 1-acetyl-8-oxa-1-azaspiro[4.5]decane-2-carboxylic acid (171) (56 mg, 0.25 mmol) and methyl {(1S)-[((2S)-2-{4-[4′-(aminoacetyl)-4-biphenylyl]-1H-imidazol-2-yl}-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate dihydrochloride (1) (142 mg, 0.25 mmol) to afford the title compound as an off-white solid (118 mg, 67% yield).

Sources & evidence

ORD record: ord-f172e1cb9e324cbc9232a561fe42044c
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08344155B2

Reaction notes

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