1-(4-Phenyloxan-4-yl)methanamine → 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((4-phenyltetrahydro-2H-pyran-4-yl)methyl)picolinamide

Participants

Reaction Steps

Following the amide bond forming procedure given in example 37, 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinic acid (intermediate B in example 1) and (4-phenyltetrahydro-2H-pyran-4-yl)methanamine (amine intermediate “X”) were reacted to give the title compound. LC/MS (M+H)+: 536. Ret. time: 1.59 min. (Condition G); analytical HPLC Ret. time: 7.85 min (Condition H)

Provenance & Evidence