4-(Aminomethyl)-4-(4-fluorophenyl)cyclohexan-1-ol → 3-fluoro-N-((1-(4-fluorophenyl)-4-hydroxycyclohexyl)methyl)-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide

Participants

Reaction Steps

Following the amide bond forming procedure given in example 37, 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinic acid (intermediate B in example 1) and 4-(aminomethyl)-4-(4-fluorophenyl)cyclohexanol (amine intermediate “T”) were reacted to give the title compound. LC/MS (M+H)+: 568. Ret. time: 1.51 min. (Condition G); analytical HPLC Ret. time: 8.11 min (Condition H).

Provenance & Evidence