(4-(2-Fluorophenyl)-1-methylpiperidin-4-YL)methanamine → 3-fluoro-N-((4-(2-fluorophenyl)-1-methylpiperidin-4-yl)methyl)-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide

Participants

Reaction Steps

The compound was prepared following the amide bond forming procedure given in example 37, 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinic acid (intermediate B in example 1) and (4-(2-fluorophenyl)-1-methylpiperidin-4-yl)methanamine (amine intermediate “Z”) were reacted to give the title compound. LC/MS (M+H)+: 567. Ret. time: 1.45 min. (Condition G); analytical HPLC Ret. time: 5.83 min (Condition H).

Provenance & Evidence