3-Fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinic acid → Tert-butyl 4-((3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamido)methyl)-4-(5-methylisoxazol-3-yl)piperidine-1-carboxylate

Participants

Reaction Steps

Following the amide bond forming procedure given in example 37, 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinic acid (intermediate B in example 1) and tert-butyl 4-(aminomethyl)-4-(5-methylisoxazol-3-yl)piperidine-1-carboxylate (amine intermediate “S”) were reacted to give the title compound. LC/MS (M+H)+: 640. Ret. time: 1.89 min. (Condition L).

Provenance & Evidence