2-Methoxyethyl chloroformate → 2-Methoxyethyl 4-((3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamido)methyl)-4-(pyridin-4-yl)piperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	2-Methoxyethyl chloroformate	HCID 69400	—
Reactant	3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((4-(pyridin-4-yl)piperidin-4-yl)methyl)picolinamide	HCID 59321425	—
Product	2-Methoxyethyl 4-((3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamido)methyl)-4-(pyridin-4-yl)piperidine-1-carboxylate	HCID 59321397	—

Reaction Steps

Following the procedure given for example 81, 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((4-(pyridin-4-yl)piperidin-4-yl)methyl)picolinamide (compound example 45) was reacted with 2-methoxyethyl chloroformate to give the title compound. LC/MS (M+H)+: 638. Ret. time: 1.31 min. (Condition I); analytical HPLC Ret. time: 5.30 min (Condition H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08343999B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-c650ad164e364830a13bdd31a1fffa83
Source note	uspto-grants-2013_01