HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylcarbamoyl Chloride → N-((1-(dimethylcarbamoyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylcarbamoyl Chloride | HCID 6598 | — |
| Reactant | 3-Fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((4-phenylpiperidin-4-yl)methyl)picolinamide | HCID 25032856 | — |
| Product | N-((1-(dimethylcarbamoyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide | HCID 59321433 | — |
Reaction Steps
Following the procedure given for example 81, 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((4-phenylpiperidin-4-yl)methyl)picolinamide (compound example 11) was reacted with dimethylcarbamic chloride to give the title compound. LC/MS (M+H)+: 606. Ret. time: 1.53 min. (Condition G); analytical HPLC Ret. time: 7.53 min (Condition H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08343999B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-d152a7a283234122986207017879fbe7 |
| Source note | uspto-grants-2013_01 |