HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-1-piperazinecarbonyl chloride → 3-Fluoro-N-((1-(4-methylpiperazine-1-carbonyl)-4-phenylpiperidin-4-yl)methyl)-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-1-piperazinecarbonyl chloride | HCID 3016935 | — |
| Reactant | 3-Fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((4-phenylpiperidin-4-yl)methyl)picolinamide | HCID 25032856 | — |
| Product | 3-Fluoro-N-((1-(4-methylpiperazine-1-carbonyl)-4-phenylpiperidin-4-yl)methyl)-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide | HCID 59321399 | — |
Reaction Steps
Following the procedure given for example 81, 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((4-phenylpiperidin-4-yl)methyl)picolinamide (compound example 11) was reacted with 4-methylpiperazine-1-carbonyl chloride to give the title compound. LC/MS (M+H)+: 661. Ret. time: 1.46 min. (Condition G); analytical HPLC Ret. time: 6.16 min (Condition H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08343999B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-456d1da25231450287966ccd01e0a835 |
| Source note | uspto-grants-2013_01 |