2-Chloro-4-fluoro-5-sulfamoylbenzoic acid → N-((1-(2-chloro-4-fluoro-5-sulfamoylbenzoyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide

Participants

Role	Name	HCID	Charge
Reactant	2-Chloro-4-fluoro-5-sulfamoylbenzoic acid	HCID 4241546	—
Reactant	3-Fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((4-phenylpiperidin-4-yl)methyl)picolinamide	HCID 25032856	—
Product	N-((1-(2-chloro-4-fluoro-5-sulfamoylbenzoyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide	HCID 59321444	—

Reaction Steps

Following the procedure given for example 92, 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((4-phenylpiperidin-4-yl)methyl)picolinamide (compound example 11) was reacted with 2-chloro-4-fluoro-5-sulfamoylbenzoic acid to give the title compound. LC/MS (M+H)+: 770. Ret. time: 2.17 min. (Condition J); analytical HPLC Ret. time: 12.91 min (Condition K).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08343999B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-784c745b96f3496a92a444f5e4c3f626
Source note	uspto-grants-2013_01