Sodium Hydroxide → HCID 67443041, compound

Participants

Reaction Steps

A mixture of 2-(4-fluoro-3-nitrophenyl)-3,3-dimethyl-1,2,3,4-tetrahydroquinoline-6-carboxylate (0.5 g, 0.52 mmol) in methanol (10 mL) and 1 M aqueous sodium hydroxide solution (26 mL, 26 mmol) was heated to reflux for 3 h. LC-MS showed the reaction was complete. The solvent was removed in vacuo and the residue was acidified with 1 M hydrochloric acid solution to pH=6. The precipitated white solid was collected by filtration and washed with water, dried in vacuo to afford 0.48 g of 2-(3-amino-4-fluorophenyl)-3,3-dimethyl-1,2,3,4-tetrahydroquinoline-6-carboxylic acid in quantitative yield.

Provenance & Evidence